Need and Opportunity
Age-related macular degeneration (AMD) is the most common cause of irreversible blindness in the western world—affecting millions of people in the U.S. alone1. While anti-VEGF therapeutics have transformed the treatment of the wet form of AMD, most patients have the dry form of the disease — for which there are no approved therapies.
As dry AMD progresses, regions of the retina are damaged, and eventually patches of atrophy can develop and expand resulting in irreversible vision loss. Since AMD typically affects central vision, which is used to read, drive a car or recognize the faces of loved ones — the impact on quality of life can be significant. Patients with certain genetic variants may have a high risk of faster disease progression and subsequent vision loss (and may also be at risk of developing systemic morbidities).